Abstract Library

#328 Report of Two First-Degree Relatives with Appendix Carcinoid and Review of the Literature

Introduction: Appendix endocrine tumors have an incidence of 2-3 patient/millon/year. They are more common in women, diagnosed incidentally during appendectomies.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: OConnor J, Pesce V, Bestani C, Cabanne A, Domenichini E,

Keywords: well-differentiated endocrine tumors of appendix, endocrine tumor of the appendix ,

#295 Unusual Behavior of Gastric Carcinoid Type 1

Introduction: Gastric carcinoids (GC) are rare tumors of the stomach. GC type 1 are associated with chronic atrophic gastritis (CAG) and are the most benign type, having low metastatic potential.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Spampatti M, Massironi S, Rossi R, Conte D, Ciafardini C,

Keywords: gastric carcinoid type 1, metastatic disease, well-differentiated endocrine tumors, Ki-67index,

#41 Immunohisochemical evaluation of EMT regulators, E- and N-cadherin in neuroendocrine Tumors of the Gastro-Entero-Pancreativ system

Introduction: Local tumor invasion represents the first step of the metastatic cascade of carcinomas, and requires changes in cell adhesion and migration properties of tumor cells. This biologic process is known as epithelial-mesenchymal transition (EMT). One key biochemical change associated with EMT is the loss of E-cadherin expression promoted by specific transcriptional repressors such as Snail, Slug, and Twist. Overexpression of EMT inducers increases other factors, such as FoxC2, although its role in EMT is poorly understood. Neuroendocrine tumors (NETs) of the gastroenteropancreatic (GEP) system, originated from the diffuse endocrine system, represent a heterogeneous group of tumors. Their prevalence has increased substantially over the past three decades, without substantial improvements in their clinical management, and their variable clinical course cannot be predicted by common clinicopathological parameters. Thus, new prognostic markers are urgently needed.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: GALVÁN J, GONZÁLEZ-MEANA M, FOLGUERAS M, ASTUDILLO A,

Keywords: gastroenteropancreatic neuroendocrine tumors, Twist, FoxC2, N-cadherin, E-cadherin, EMT,

#38 Expression of mTOR signaling pathway and effects of mTOR inhibitors on its pathway in human neuroendocrine tumors

Introduction: Neuroendocrine tumors (NET), especially well-differentiated endocrine tumors, are often slow-growing, indolent, and may not become clinically apparent until the manifestations of metastatic spread or carcinoid syndrome. Results of previous studies demonstrated that phosphoinositide 3-kinase (PI3K)/Akt/mTOR signaling pathway may be activated in the great majority of NET cells. mTOR inhibitors are therefore considered effective anti-tumor reagents but they may also induce an activation of PI3K/Akt and MAPK pathways as a compensatory action and reduce their own anti-tumor activities.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Sasano H

Authors: Iida S, Miki Y, Ono K, Sasano H,

Keywords: neuroendocrine tumors, mTOR inhibitors, MEK inhibitors, combination therapy,